Micro-gravity exposure results in significant atrophy of murine skeletal muscle without alterations in myosin heavy chain gene expression. B Harrison, D Allen, L Stodieck, P Kostenuik, T Bateman, S Morony, L Leinwand. Am Soc Gravitation Space Biol 2002 (Abstract)

Skeletal muscle adaptations to microgravity exposure in the mouse. Harrison BC, Allen DL, Girten B, Stodieck LS, Kostenuik PJ, Bateman TA, Morony S and Leinwand LA. J Applied Physiol 95: 2462-2470, 2003. PMID: 12882990*

Bone loss associated with spaceflight and botox-induced muscle paralysis is ameliorated by RANKL inhibition. Warner SE, Bateman TA, Morony S, Ferguson VL, Simske SJ, Lacey DL, Warmington KS, Geng Z, Tan HL, Shalhoub V, Dunstan CR, Kostenuik PJ and Gross TS.  Osteoporosis Int 17 (Suppl. 2): S117-118, 2006 (Abstract)

Effects of spaceflight on murine skeletal muscle gene expression. Allen DL, Bandstra E, Harrison BC, et al. J Appl Physiol 106: 582-595, 2009. PMID: 19074574

RANKL inhibition prevents the loss of bone volume and bone strength caused by botox-induced muscle paralysis.  Warner SE, Srinivasan S, Kostenuik PJ, and Gross TS. Trans Orthop Res Society 31: 0217, 2006 (Abstract)

Transient muscle paralysis degrades bone via rapid osteoclastogenesis. Aliprantis AO, Stolina M, Kostenuik PJ, et al. FASEB J 26: 1110-1118, 2012. PMID: 22125315


 

Some of Dr. Kostenuik's publications in the muscle field:

Muscle was the first tissue Paul studied as an undergraduate studying Exercise Physiology. After undergoing 22 skeletal muscle biopsies as part of an endurance training study, Paul analyzed the fiber types of his own vastus lateralis samples (the results of which revealed the cellular basis of his underwhelming athletic traits). His research in muscle continued with studies examining the effects of muscle disuse, which included two space shuttle experiments as well as ground-based models that mimic clinical conditions such as spinal cord injury and bed rest. As a result of his work with NASA on the Shuttle STS-108  mission, which led to a more detailed understanding of molecular changes in skeletal muscle during microgravity (see PMID 12882990*), Paul was recently awarded the NASA Exceptional Public Achievement Medal.

Muscle